Lipid metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of lipids does not increase to toxic levels and that they are available at sufficient amounts for processes requiring them. Disruption of this balance is at the center of several pathological conditions in humans, most notably fatty liver and cardiovascular disease.
Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism (e.g Zelcer et al., Science 2009; Zelcer et al. MCB 2014; Sharpe et al. TIBS 2014; Loregger et al. MCB 2015; Nelson et al. Circ Res 2016; Loregger et al. ATVB 2017; van Loon et al. ATVB 2018). We have recently used genome-wide functional genetic screens to identify novel genes that play a role in the regulation of cholesterol metabolism. In this VICI-supported project we will apply CRISPR/Cas9- or haploid-based genome-wide functional genetic approaches to study lipid-associated cellular processes including, amongst others, cholesterol and fatty acid synthesis and intracellular sterol trafficking. The goal of this project is to identify novel genes and elucidate the molecular mechanisms that govern the aforementioned processes, and ultimately investigate whether these play a role in cardiovascular and metabolic disease. A wide range of advanced techniques will be used in this project, including state-of-the-art genetic screens, cell-based functional assays, metabolomics, mass spectrometry, and molecular biology.
We are looking for a broadly-trained and highly-motivated scientist with a PhD in Medical Biology, Life Sciences, Biochemistry or a related field. Experience with functional genetic screens, next-generation sequencing, or bioinformatics is an advantage. The candidate should have good command of oral and written English. Excellent communication skills and the ability to work within an international research group are essential.
The Zelcer group is located in the Department of Medical Biochemistry. Additional information on our research and group can be found on our website: http://www.zelcerlab.eu/.
We offer a fulltime position for a period of 2 years, with ample possibility for extension. The salary is in accordance with CAO-UMC and will start from scale 10 and is commensurate with qualifications and experience (minimum € 3.403,- and maximum € 4.481,-). In addition payment includes a holiday allowance of 8%, a year-end bonus of 8.3% of the gross annual salary, compensation of travel expenses as well as free parking. You will be employed by AMC Medical Research BV.
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If you would like more information, please feel free to contact Noam Zelcer (email@example.com).
Applications should include a CV, cover letter and the contact information of three references. An assessment may be part of the selection procedure.
We look forward to meeting you!