Lipid metabolism is tightly regulated both at the cellular as well as whole-organism level. This regulation ensures that the level of lipids does not increase to toxic levels and that they are available at sufficient amounts for processes requiring them. Disruption of this balance is at the center of several pathological conditions in humans, most notably fatty liver and cardiovascular disease.
Our group is broadly interested in the transcriptional and post-transcriptional regulation of lipid and energy metabolism (e.g Zelcer et al., Science 2009; Zelcer et al. MCB 2014; Sharpe et al. TIBS 2014; Loregger et al. MCB 2015; Nelson et al. Circ Res 2016; Loregger et al. ATVB 2017; van Loon et al. ATVB 2018). A major research line in the lab addresses the role of recently identified E3 ubiquitin ligases (MARCH6 & RNF145) in regulating lipid metabolism and as such a central goal of this VICI-supported project is to elucidate the role of these ligases in lipid metabolism in vitro at the mechanistic and cellular level (using e.g. CRISPR/cas9, molecular biology, RNAseq, metabolomics, mass spectrometry, functional assays), as well as to evaluate their contribution to development of metabolic disease in vivo in mice.
As part of this VICI project we have developed several new conditional mouse models of the identified ligases that are implicated in lipid and energy metabolism. We are looking for a broadly-trained and highly-motivated scientist with a PhD in Medical Biology, Life Sciences, Biochemistry or a related field. Experience and affinity with animal experiments and holding an article 9 certificate (or equivalent animal handling diploma) is an advantage. The candidate should have good command of oral and written English. Excellent communication skills and the ability to work within an international research group are essential.
The Zelcer group is located in the Department of Medical Biochemistry. Additional information on our research and group can be found on our website: http://www.zelcerlab.eu/.
We offer a fulltime position for a period of 2 years, with ample possibility for extension. The salary is in accordance with CAO-UMC and will start from scale 10 and is commensurate with qualifications and experience (minimum € 3.403,- and maximum € 4.481,-). In addition payment includes a holiday allowance of 8%, a year-end bonus of 8.3% of the gross annual salary, compensation of travel expenses as well as free parking. You will be employed by AMC Medical Research BV.
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If you would like more information, please feel free to contact Noam Zelcer (email@example.com).
Applications should include a CV, cover letter and the contact information of three references. An assessment may be part of the selection procedure.
We look forward to meeting you!